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7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ...Solubility diagrams were obtained according to Higuchi and Connors (1965). Excess amounts of sulfamethizole were added to water containing various concentrations of cyclodextrins and the suspensions were shaken at 37°C. ... Phase solubility techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus Google Scholar. Job, …All solubility measurements were performed six times. 2.2.2. Phase solubility study. Phase solubility study was performed according to the method described by Higuchi and Connors [17]. An excess amount of aceclofenac was placed in a 25 ml glass flask containing different concentrations of polymers in 20 ml distilled water.

To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.

A phase-solubility study, where the drug (i.e. the substrate) solubility in moles/liter is plotted against the molar CD (i.e. the ligand) concentration, is one of the most common methods applied. Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles ( Higuchi and Connors, 1965 ).PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ... ….

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Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.Moreover, phase-solubility analysis shows that propyl-paraben and ethylparaben, at room temperature, can also form solid solutions whose solubility is related to the composition of the solid phase at equilibrium. ... T. Higuchi, A. Connors. Phase-solubility Techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus …

2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...

online degree in behavioral science This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …Solubility diagrams were obtained according to Higuchi and Connors (1965). Excess amounts of sulfamethizole were added to water containing various concentrations of cyclodextrins and the suspensions were shaken at 37°C. ... Phase solubility techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus Google Scholar. Job, … 7 gallon bucket lowe's20 inch huffy bike The phase solubility diagram (Fig. 2) showed that the solubility of cholesterol increased linearly with increasing β-CD concentration from 0 to 18 mmol/L (R 2 > 0.99). The phase solubility diagram was defined as the A L -type phase based on the early research of Higuchi and Connors (1965) , revealing the formation of inclusion complex …Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. fighting for par The mole fraction solubility of TDL was found to be highest in pure PEG 400 (1.86 × 10- 2 at 298.15 K) as compared to water (5.7 × 10- 7 at 298.15 K). The thermophysical parameters such as enthalpies and entropies for TDL dissolution indicated that the dissolution of TDL is endothermic and an entropy-driven process.Phase solubility. Compatibility of host and guest relationship was determined by Higuchi-Connors phase solubility method [16]. Excess amount of drug was added in flask containing different molar ratios of βCD mixed in distilled water. Flasks were placed in water bath (TSSWB15-USA) at 37 ± 2 °C with speed of 100 rpm for 72 h. 700 dawn street richmond vahow to make bylawscole ballard westfield Phase solubility studies. Increasing concentrations (0-10 mM) of CD solutions were added to a series of stoppered glass tubes containing an excess amount of PD at 25°C, according to the method reported by Higuchi and Connors (1965).2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels … well drilling kansas city In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations.In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation. zillow adams county ohioelizabeth watkinsbars that show ppv fights The influence of both temperature and CYD concentration on complex solubility was studied using the method of Higuchi and Connors (Adv. Anal. Chem., 4 (1965) 117–212). This is based on monitoring changes in the solubility of substrate (salbutamol) on the addition of complexing agents (α-, β-, Me-β- and γ-CYD).